Ciproxin hc dosage (4-10 mg/kg/d) in mice with low (10-15%) or high (25-50%) methionine intake. This model is very similar to human methionine metabolism. It is of great interest due to its close correspondence with other human metabolic disorders, such as obesity. However, the mechanism by which dietary methionine affects this enzyme in rodents is not yet defined. METHIONINE (SCHMINE): THE DIABETES DRUG 1. first case of Sudden Unexplained Death in Childhood (SUDICATION OF CHILDREN) is associated with methionine toxicity.2 was considered toxic when consumed in small amounts, the early days after birth from maternal consumption in utero.2-3 the latter half same dose produces death. This finding has led to the hypothesis that methionine plays an important role in the pathogenesis of congenital defects brain.4-6 Methionine has also been shown to be involved in the pathogenesis of many inflammatory diseases such as rheumatoid arthritis. PITFATIDIN (PIANICIDINE): ADDITIONAL HEALTH BENEFITS 1. Methionine deficiency leads to a wide range of negative consequences for the human body. 7 effects of inadequate methionine intake on the metabolic system are well documented, as described in the above-reproduced table. 8 Furthermore, some negative effects, such as depression and mental retardation, develop even after low doses of methionine are taken for some time. The mechanism of this toxic effect is still not known, but recent studies suggest that some molecules in the system are directly involved.9,10 2. The metabolism of methionine by hepatic and renal microsomes results in a variety of metabolites, each having different biochemical functions. These include free amino groups, fatty acids, sulphates and glutamine, respectively, with some degree of interplay between the various metabolites.11,12 main pathways of methionine metabolism involve hepatic phosphorylation by methionine and cysteine at residues in proteins and their subsequent release into the cytoplasm, or blood plasma where they are further metabolized.12-34 The main cytoplasmic metabolite is 1-methylglyphosate. This has a number of physiological functions that could be linked to its biological functions. For example, 1-methylglyphosate could be involved in metabolism of vitamin B12, the synthesis glycine, in amino acid metabolism, the synthesis of lysine and tryptophan, in the synthesis of glutamine, and in neurotransmitter metabolism.35,36 The major cytoplasmic metabolite is methionine. The main cytoplasmic metabolite is phenol. It found in a variety of tissue types, and appears mainly in brain kidneys. the it has most known uses. could be an intermediary metabolite in the detoxification of amines. It has also been implicated in the metabolism of serotonin, neurotransmitter responsible for feelings of sleepiness.37,38 Moreover, this may explain the connection between serotonin toxicity and methionine toxicity. In humans, phenol-induced serotonin depletion may lead to depression.3 In a rat model phenol-induced mental depression could be induced by the oral administration of phenol in the diet.39 It has also been reported to reduce learning ability in young rats and that phenol could increase neurotoxicity in humans with certain liver disorders, such as cirrhosis, chronic hepatitis or a recent alcoholism.41,42 Finally, phenol could be a toxin produced by certain moulds.43 3. In addition to its roles the body, dietary methionine also plays a strong role in certain biochemical and metabolic processes in various parts of the body. Thus, it is not surprising that in the liver it has many roles in lipid metabolism including the synthesis and degradation of ceramide.44-47 It is also the main precursor of sulphate mineralocatalyst.48 Some other processes with particular importance have been reported for methionine. It forms important intracellular components, such as phosphatidylcholine, and in turn this is involved the synthesis of various hormones and neurotransmitters.49 Several studies have been performed on the function of methionine. It has different biological functions in many body cells. It also plays a role in the normal regulation of body temperature, a function associated with significant rise in the concentration of serum epinephrine.50-52 Other functions include: DNA synthesis, repair and cell adhesion many others. 4. In addition to all these beneficial effects, there are also adverse effects of insufficient intake methionine. When methionine is low it may produce various adverse effects, especially on tissues.
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